Oh yeah - I've been testing the changing multis with new patterns via direct access. For me there's always a noticeable pause - sometimes musical - but mostly annoying, even if the is only one instrument track playing. Still, in the background, pretty handy (as is Direct pattern access)
A noticeable dropout in the audio, or a pause where the sequencer misses time? If you were just using the sequencer to trigger external gear, would you notice it? I love Direct Pattern Access, but I'd like a way to get more than 16 patterns, and it would be cool to create a few different multi setups as different "banks" of patterns for Direct Pattern Access.
--Dan