Homebrew PCBs

Best way to cut it out most likely would be a CNC router.  

But most likely you need to do it by hand, so I would say the idea of
drilling the back of each slot with the correct sized drill bit and
then cutting straight cuts with a saw to finish making the slots, saw
by hand with a hacksaw would be one way, Scroll saw or band saw which
would be faster would be good ways,  a table saw with fine tooth
carbide blade or dry/wet diamond blade or the wet tile saw to make the
short straight cuts.  If you go with the table saw cutting dry you
will need a good Vac setup for fine dust.

Yes FR4 is tough on saw blades, and HSS drill bits.


Ben