If it were me, I'd use my scroll saw, but that would go through blades pretty quickly, unless it's phenolic. FR4 is hard on saw blades. If you start by drilling the holes at the bottoms of each cutout (11 big ones and 10 little ones) at least it would be all straight cuts with the scroll saw.
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Re: [Homebrew_PCBs] Cutting a pcb
2008-08-29 by DJ Delorie