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Depend on what you use the acrylic for. MANY years ago (1970 or so) at the Lawrence Radiation Lab, we used a pair of massive acrylic beams (2" thick, 24" wide, 10ft long) to support a 3MV Cockroft -Walton generator. Wiped them down with alky before sealing them in the HV pressure vessel, then had to replace the entire assembly because of stress cracks. If it's not a structural element, you're probably safe.It may depend on denaturing agents as well as the particular acrylic grade.Personally I wouldn't hesitate to clean acrylic with denatured ethanol, since I have never observed this, but you are not the only one saying it has this effect.
Norm