[sdiy] LTSpice for large circuits?

[JH.]

Hi,

seems I must say Goodbye to PSpice ...
I have an old unsupported 8.0 Version that doesn't seem to recognize the security plug anymore (tried a lot of things to fix the 
problem, and finally give up).

I'm looking for an alternative. LTSpice seems to be popular because it's free. But before I start to learn user interface of that 
program, I'd like to know if LTSpice will be good enough for really huge circuits (like, a vocoder with 100 opamps) - or are there 
any limitations?

I'm also looking for recommendations for other Simulation programs.
Doesn't have to be freeware, but I don't want to spend a big amount of money - smething in the 100 ... 200 EUR range would be nice.
Comfortable user interface is 1st priority, because I'm going to use this a *lot*.

Thanks in advance,

JH.