PCB construction question

[John Speth]

Hey all you PCB builders...

Lately I've found myself seriously considering making my own PCBs.  I've identified 2 routes - 1) do the photomasking and etching myself (inexpensive but messy) or 2) use a professional PCB fab service (very expensive but results are +++).  In considering #1, I'm always faced with the big problem of How do I drill the holes accurately?  I suppose a drill press would be the way to go but one big mistake and the board's probably shot.  

So my question is to you who DIY your own PCBs, How do you drill so many holes accurately?  Any hints or help offerered is greatly appreciated.  

Thanks...

John Speth
Object Engineering, Inc.
johns at oei.com